2017-8-11 16:0:3Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)
description
similar to phage shock protein, resistance against oxidative stress and cell wall antibiotics (such as daptamycin), secondary bacitracin resistance determinant
similar to phage shock protein, resistance against oxidative stress and cell wall antibiotics (such as daptamycin)
proteinLength
225
geneLength
675
Gene
Coordinates
3,397,846 → 3,398,523
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
Mutant
MGNA-B039 (yvqH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1038 NBRP B. subtilis, Japan]
References
Original publications
aminos
[SW|Categories] containing this gene/protein
[SW|resistance against oxidative and electrophile stress], [SW|resistance against toxins/ antibiotics]
Gene
Coordinates on the chromosome (coding sequence)
3,397,846 -> 3,398,523
The protein
[SW|Interactions]
forms large oligomeric rings with a nine-fold rotational symmetry [Pubmed|20639339]
[[protein|LiaI]]-[[protein|LiaH]] [Pubmed|24666271]
Expression and Regulation
Operon
''[[protein|liaI]]-[[protein|liaH]]-[[protein|liaG]]-[[protein|liaF]]-[[protein|liaS]]-[[protein|liaR]]'' [Pubmed|14651641]
''[[protein|liaI]]-[[protein|liaH]]'' [Pubmed|20639339]
Expression and Regulation
[SW|Sigma factor]
[[protein|SigA]] [Pubmed|15273097]
Expression and Regulation
Regulation
induced by bacitracin and rhamnolipids ([[protein|LiaR]]) [Pubmed|16816187,22092710]
induced by daptomycin [Pubmed|27791134]
repressed during logarithmic growth ([[protein|AbrB]]) [PubMed|15101989,17660417], indirect regulation by [[protein|AbrB]] [Pubmed|20817675]
Expression and Regulation
Regulatory mechanism
[[protein|LiaR]]: transcription activation [Pubmed|16816187]